Jonathan C Jarvis Selected Research

Ochronosis

1/2021	Anatomical Distribution of Ochronotic Pigment in Alkaptonuric Mice is Associated with Calcified Cartilage Chondrocytes at Osteochondral Interfaces.
1/2020	Homogentisic acid is not only eliminated by glomerular filtration and tubular secretion but also produced in the kidney in alkaptonuria.
1/2020	Efficacy and safety of once-daily nitisinone for patients with alkaptonuria (SONIA 2): an international, multicentre, open-label, randomised controlled trial.
1/2020	Dietary restriction of tyrosine and phenylalanine lowers tyrosinemia associated with nitisinone therapy of alkaptonuria.
1/2015	Nitisinone Arrests but Does Not Reverse Ochronosis in Alkaptonuric Mice.
5/2013	Recent advances in management of alkaptonuria (invited review; best practice article).

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Jonathan C Jarvis Research Topics

Disease

13	Alkaptonuria 07/2022 - 02/2011
6	Atrophy 01/2021 - 01/2007
6	Ochronosis 01/2021 - 05/2013
3	Hypertrophy 01/2022 - 01/2019
3	Fatigue 04/2010 - 07/2003
2	Tyrosinemias (Tyrosinemia) 01/2020 - 01/2019
2	Muscular Atrophy (Muscle Atrophy) 12/2017 - 07/2008
2	Paralysis (Palsy) 10/2015 - 01/2011
2	Heart Failure 01/2015 - 03/2002
2	Joint Diseases (Joint Disease) 01/2014 - 02/2011
1	Atrophic Muscular Disorders 01/2022
1	Fibrosis (Cirrhosis) 01/2021
1	Body Weight (Weight, Body) 05/2020
1	Disease Progression 01/2020
1	Tyrosinosis 01/2020
1	Sarcopenia 12/2018
1	Atrioventricular Septal Defect 01/2018
1	Heart Block 01/2018
1	Metabolic Diseases (Metabolic Disease) 01/2014
1	Inborn Genetic Diseases (Disease, Hereditary) 02/2011

Drug/Important Bio-Agent (IBA)

9	Homogentisic AcidIBA 01/2021 - 02/2011
8	nitisinone (Orfadin)FDA Link 05/2022 - 01/2014
6	Tyrosine (L-Tyrosine)FDA Link 07/2022 - 02/2011
5	EnzymesIBA 07/2022 - 02/2011
5	Homogentisate 1,2-Dioxygenase (Homogentisate 1,2 Dioxygenase)IBA 07/2022 - 05/2013
3	Proteins (Proteins, Gene)FDA Link 01/2021 - 01/2019
2	Ion Channels (Ion Channel)IBA 01/2021 - 01/2015
2	Messenger RNA (mRNA)IBA 01/2021 - 01/2015
2	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 01/2021 - 01/2019
2	Phenylalanine (L-Phenylalanine)FDA Link 01/2020 - 01/2015
2	PolymersIBA 01/2014 - 05/2013
2	Protein Isoforms (Isoforms)IBA 08/2006 - 07/2003
1	Neurotransmitter Agents (Neurotransmitter)IBA 05/2022
1	CollagenIBA 01/2021
1	ConnexinsIBA 01/2021
1	Drinking WaterIBA 05/2020
1	Dietary ProteinsIBA 01/2020
1	Amino Acids FDA Link 01/2020
1	Ligases (Synthetase)IBA 01/2019
1	Connexin 43 (Connexin43)IBA 01/2015
1	Atrial Natriuretic Factor (ANF)IBA 01/2015
1	Melanins (Melanin)IBA 05/2013
1	beta-cyclodextrin tetradecasulfate (CTDS)IBA 02/2011
1	Myosin Heavy Chains (Myosin Heavy Chain)IBA 08/2006
1	Myosins (Myosin)IBA 07/2003

Therapy/Procedure

4	Therapeutics 01/2020 - 01/2011
4	Denervation 12/2017 - 01/2007
1	Resistance Training 01/2022
1	Endurance Training 01/2022
1	Intraperitoneal Injections 05/2020
1	Diet Therapy (Therapy, Diet) 01/2020
1	Nerve Crush 01/2019
1	Operative Surgical Procedures 12/2018
1	Lasers (Laser) 01/2015
1	Electrodes (Electrode) 04/2010
1	Heart Transplantation (Grafting, Heart) 03/2002